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出生年月

1982.08

工      號

科　　別

護(hù)理學(xué)院

職　　稱

中級

最高學(xué)歷

博士

職      務(wù)

講師

最高學(xué)位

博士研究生

畢業(yè)院校

中山大學(xué)

導(dǎo)師（打√）

碩 √  博 口

學(xué)      科

護(hù)理學(xué)

應(yīng)診時間：

出診科室

聯(lián)系電話：

15626209898

電子郵箱：

[email protected]

個人簡介（包括主要的學(xué)習(xí)工作經(jīng)歷、醫(yī)療專長,、教學(xué)情況等）

2016年6月中山大學(xué)藥學(xué)院博士畢業(yè)，畢業(yè)后繼續(xù)在中山大學(xué)第一附屬醫(yī)院從事博士后相關(guān)研究工作,，博士和博士后期間主要研究心腦血管相關(guān)疾病的病因和發(fā)病機(jī)制,，并探討該類疾病新的治療靶點(diǎn)。現(xiàn)已發(fā)表SCI論文15篇,，總計影響因子61.8分,。博士后出站后于2017年11月到暨南大學(xué)護(hù)理學(xué)院從事教學(xué)和科研的相關(guān)工作，目前主要擔(dān)任《社區(qū)護(hù)理》,、《臨床藥理》和《外科護(hù)理學(xué)》課程的主講工作,。

社會任職

現(xiàn)任廣東省護(hù)理學(xué)會護(hù)理信息專業(yè)委員會主委

研究方向（臨床、課題）

臨床護(hù)理,、護(hù)理藥理和慢性病的延續(xù)護(hù)理

榮譽(yù)與獎勵

無

學(xué)術(shù)論著（近年發(fā)表的主要論文,，專著請寫明專著書名）

(1) Rifang Liao^#*, Fengxia Yan^#, Zhuanping Zeng^#, Haitao Wang, Kaifeng Qiu, Jinying Xua，Wenhua Zheng^*, Insulin-like growth factor-1 activates PI3K/Akt signalling to protect human retinal pigment epithelial cells from amiodarone-induced oxidative injury, Br J Pharmacol, 2018 Jan;175(1):125-139. (并列第一作者,，IF=6.58)

(2) Yizhou Jiang^#, Fengxia Yan^#, Zhongping Feng, Philip Lazarovici, Wenhua Zheng^*,Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction,，Cells, 2019 Dec 31;9(1). DOI: 10.3390/cells9010100, [Epub ahead of print]( 并列第一作者, IF=5.66)

(3) Fengxia Yan^#, HuaMing Li^#, ShangXuan Li^#, ShiHui He, WeiPing Dai, Yan Li, Tian Tian Wang, MaoMao Shi, HaoXiang Yuan, Zhe Xu, JiaGuo Zhou, DaSheng Ning, ZhiWei Mo, ZhiJun Ou^*, JingSong Ou^*, The oxidized phospholipid POVPC impairs endothelial function and vasodilation via uncoupling endothelial nitric oxide synthase, J Mol Cell Cardiol, 2017 Nov;112:40-48. （第一作者，IF=5.3）

(4) Rifang Liao^#, Fengxia Yan^#, Zhuanping Zeng^#, Mohd Farhan, Peter Little, Remi Quirion, Lalit K. Srivastava, Wenhua Zheng^*, Amiodarone-Induced Retinal Neuronal Cell Apoptosis Attenuated by IGF-1 via Counter Regulation of the PI3k/Akt/FoxO3a Pathway, Mol Neurobiol, (2017) 54:6931–6943. (并列第一作者,，IF=4.58).

(5) Fengxia Yan^#, Rifang Liao^#, Marta Silva^#, Shuai Li^#, Yizhou Jiang, Tangming Peng, Philip Lazarovici,  Wenhua^*,ZhengPristimerin-induced uveal melanoma cell death via inhibiting PI3K/Akt/FoxO3a signalling pathway. J Cell Mol Med. 2020 Apr 29. doi: 10.1111/jcmm.15249. [Epub ahead of print]( (第一作者,，IF=4.66).

(6) Fengxia Yan^#, HaiTao Wang^#, Yang Gao, Jiang Ping Xu, and Wenhua Zheng^*, Artemisinin Protects Retinal Neuronal Cells against Oxidative Stress and Restores Rat Retinal Physiological Function from Light Exposed Damage, ACS Chem Neurosci, 2017 Aug 16;8(8):1713-1723. (第一作者，IF=3.86)

(7) Xiaoying  Zhang^#,，Lifang Wang ^#, Lizhi Peng^#,，Xiaoying Tian, Xiaoyuan Qiu, Huan Cao, Qiaohong Yang^*,Rifang Liao^* and Fengxia Yan^*,，Dihydromyricetin protects HUVECs of oxidative damage induced by sodium nitroprusside through activating PI3K/Akt/FoxO3a signalling pathway，J Cell Mol Med. 2019 May 21,； doi: 10.1111/jcmm.14406,，[Epub ahead of print].（通訊作者，IF=4.66）

(8) Fengxia Yan^#, Zilong Gao, Pin Chen, Li Huang, Dangui Wang, Na Chen, Ruixiang Wu, Jing Feng, Shan Cui, Wei Lu, JinHui Wang^*, Coordinated Plasticity between Barrel Cortical Glutamatergic and GABAergic Neurons during Associative Memory. Neural Plast, 2016 Dec 14. doi: 10.1155/2016/5648390,，[Epub ahead of print]. （第一作者,，IF=3.59）

(9) Fengxia Yan ^#, Rifang Liao^#, Mohd Farhan, Tinghuai Wang, Jiashu Chen, Zhong Wang, Peter J. Little, Wenhua Zheng^*, Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells, Biomedicine & Pharmacotherapy, 2016, 84(12): 1538–1550. (第一作者，IF=3.74)

(10) Rikang Wang^#, Fengxia Yan ^#, Rifang Liao^#, Pei Wan, Peter J.Little , Wenhua Zheng^*, Role of brain-derived neurotrophic factor and nerve growth factor in the regulation of Neuropeptide W in vitro and in vivo, Mol Cell Endocrinol, 2017 May 15;447:71-78. （并列第一作者,，IF=3.69）

(11) Fengxia Yan^#, Rifang Liao^#, Peter J. Little, Wenhua Zheng^*, Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl2like protein 11 and cyclindependent kinase inhibitor 1B, Molecula Medicine Reports. 2018 Feb;17. doi: 10.3892/mmr.2017.8215, [Epub ahead of print].（第一作者,，IF=1.85)

(12) Wenhua Zheng^*, Qian Meng, Haitao Wang, Fengxia Yan, Peter J. Little, Xinguo Deng, Shaofen Lin, IGF-1-Mediated Survival from Induced Death of Human Primary Cultured Retinal Pigment Epithelial Cells Is Mediated by an Akt-Dependent Signaling Pathway, Mol Neurobiol (2018) 55:1915–1927.(第四作者，IF=4.58)

(13) Shuai Li^#,，Shubhash Chandra chaudhary^#, Xia Zhao^#, Uma Gaur,，Jiankang Fang, Fengxia Yan and Wenhua Zheng^*，Artemisinin Protects Human Retinal Pigmented Epithelial Cells Against Hydrogen Peroxide-induced Oxidative Damage by Enhancing the Activation of AMP-active Protein Kinase, International Journal of Biological Sciences, 2019;15:2016-2028.(第六作者,，IF=4.06)

(14) Haitao Wang^#, Sufei Liao^#, Ruojun Geng, Yongxin Zheng, Rifang Liao, Fengxia Yan, Thilini Thrimawithana, Peter J. Little, Zhongping Feng, Philip Lazarovici, Wenhua Zheng^*, IGF-1 signaling via the PI3K/Akt pathway confers neuroprotection in human retinal pigment epithelial cells exposed to sodium nitroprusside insult, Journal of Molecular Neuroscience, 2015, 55(4):931-40. (第六作者,，IF=2.57)

(15) Liu Linlin^#, Zhiwen Zeng, Uma Gaur, Fengxia Yan and Wenhua Zheng^*，The p38-MAPK Pathway Is Involved in Neuroprotection of Artemisinin against H2O2-induced Apoptosis in PC12 Cells,，Journal of Pharmacy and Pharmacology,，7 (2017) 416-423（第四作者，IF=2.39).

科研項目

(1) FoxO3a對eNOS表達(dá)的調(diào)控在趨炎HDL介導(dǎo)血管舒張功能受損中的作用及機(jī)制研究,，廣州市基礎(chǔ)與應(yīng)用基礎(chǔ)研究項目,，主持，20萬

(2) FoxO1轉(zhuǎn)錄因子對神經(jīng)肽W表達(dá)的調(diào)控在抑郁癥形成中的作用及機(jī)制研究,，廣東省自然科學(xué)基金面上項目，主持10萬

(3) 青蒿素對H2O2誘導(dǎo)視網(wǎng)膜色素上皮細(xì)胞凋亡的保護(hù)作用及機(jī)制研究,，暨南大學(xué)護(hù)理學(xué)院培育項目,，主持，3萬

(4) 青蒿素對氧化損傷視網(wǎng)膜色素上皮細(xì)胞的保護(hù)作用及機(jī)制的研究,，廣東省中藥局項目,，主持，1萬

Fox03a 轉(zhuǎn)錄因子在葡萄膜黑色素痛中的作用及調(diào)節(jié)機(jī)制研究,，廣東省醫(yī)學(xué)科研基金立項課題,，主持，0.5萬